A case of hereditary amyloidosis transthyretin variant Met 30 with amyloidcardiomyopathy, less polyneuropathy, and the presence of giant cells

Transthyretin-Met 30 (TTR-Met 30) is a variant of transthyretin and is usua lly associated with familial amyloid polyneuropathy. It is rare that patien ts with TTR-Met 30 will primarily develop amyloid cardiomyopathy. This repo rt presents a patient with late-onset TTR-Met 30 who primarily developed am yloid cardiomyopathy, with less amyloid polyneuropathy in the peripheral ne rvous system than is usually seen. An autopsy was performed, and histologic al examination revealed many foreign-body giant cells and macrophages in th e area of amyloid deposition that was found in nearly all of the organs.