Optimization of gene sequences under constant mutational pressure and selection

Authors
Kowalczuk, M Gierlik, A Mackiewicz, P Cebrat, S Dudek, MR
Citation
M. Kowalczuk et al., Optimization of gene sequences under constant mutational pressure and selection, PHYSICA A, 273(1-2), 1999, pp. 116-131
Citations number
19
Categorie Soggetti
Physics
Journal title
PHYSICA A
ISSN journal
03784371 → ACNP
Volume
273
Issue
1-2
Year of publication
1999
Pages
116 - 131
Database
ISI
SICI code
0378-4371(19991101)273:1-2<116:OOGSUC>2.0.ZU;2-V
Abstract
We have analyzed the influence of constant mutational pressure and selectio n on die nucleotide composition of DNA sequences of various size, which wer e represented by the genes of the Borrelia burgdorferi genome. With the hel p of MC simulations we have found that longer DNA sequences accumulate much less base substitutions per sequence length than short sequences. This lea ds us to the conclusion that the accuracy of replication may determine the size of genome. (C) 1999 Elsevier Science B.V. All rights reserved.