COMBINED TOXICITY OF FLUORIDE AND BENZENE HEXACHLORIDE TO RATS

Authors
RAMESH N MOHAN EM PRIYA CAYB STANLEY VA PILLAI KS MURTHY PB
Citation
N. Ramesh et al., COMBINED TOXICITY OF FLUORIDE AND BENZENE HEXACHLORIDE TO RATS, Fluoride, 30(2), 1997, pp. 105-109
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Fluoride → ACNP
ISSN journal
00154725
Volume
30
Issue
2
Year of publication
1997
Pages
105 - 109
Database
ISI
SICI code
0015-4725(1997)30:2<105:CTOFAB>2.0.ZU;2-T
Abstract
Sprague-Dawley rats were given various treatments of 10 ppm fluoride, 25 ppm fluoride, 25 ppm benzene hexachloride (BHC), 10 ppm fluoride 25 ppm BHC, or 25 ppm fluoride + 25 ppm BHC for 16 weeks ad libitum. R ats showed a decrease in body weight gain, which could be attributable to BHC alone. A synergistic effect of fluoride and BHC was seen only in females given 25 ppm fluoride + 25 ppm BHC: a decrease in red blood cells (RBC) and relative weight of the ovary. Females were more susce ptible to the toxicity of fluoride and BHC than males.