Changes in immunomodulatory activity of human mononuclear cells after cultivation with leaf decoctions from the genus Ligustrum L.

Leaf decoctions from Ligustrum vulgare (LV) and Ligustrum delavayanum (LD) were studied for candidacidal activity, phagocytic activity studied on huma n mononuclear cells (MO) and complement activated by the classical pathway. Candidacidal activity was studied on Candida albicans SC 1539 incubated wi th MO. The decoction of LD increased the candidacidal activity of MO, where as LV did not show any effect. The phagocytic activity of MO was decreased bg:the decoction of LV, whereas LD did not change the activity. The phagocy tic index of MO incubated with LD decoction was increased, but use of the L V decoction did not show significant changes. Decoctions from LD and LV sig nificantly decreased the haemolytic activity of complement activated by the classical pathway (conc, 0.78 mg/mL), Copyright (C) 1999 John Wiley & Sons , Ltd.