Analysis of a de novo complex chromosome rearrangement involving chromosomes 4, 11, 12 and 13 and eight breakpoints by conventional cytogenetic, fluorescence in situ hybridization and spectral karyotyping

A complex chromosome rearrangement (CCR) with:eight breakpoints resulting i n four derivative chromosomes (4, 11, 12 and 13) was detected prenatally in a male fetus of a twin pregnancy. The karyotype of the female second fetus was normal. The apparently balanced de novo CCR was identified by classica l cytogenetic methods and fluorescence in situ hybridization (FISH). We com pared these findings with results from spectral karyotyping (SKY). Copyrigh t 1999 John Wiley & Sons, Ltd.