Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons

Authors
Xu, ZQD Ma, XS Soomets, U Langel, U Hokfelt, T
Citation
Zqd. Xu et al., Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons, P NAS US, 96(25), 1999, pp. 14583-14587
Citations number
60
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
96
Issue
25
Year of publication
1999
Pages
14583 - 14587
Database
ISI
SICI code
0027-8424(199912)96:25<14583:EEFAHG>2.0.ZU;2-C
Abstract
The effects of the 29-amino acid neuropeptide galanin [GAL (1-29)], GAL(1-1 5). GAL(1-16). and the GAL subtype 2 receptor agonist D-tryptophan(2)-GAL(1 -29) were studied in the dorsal hippocampus in vitro with intracellular rec ording techniques. GAL(1-15) induced. in the presence of tetrodotoxin, a do se-dependent hyperpolarization in hippocampal CA3 neurons. Most of the GAL( 1-15)-sensitive neurons did not respond to GAL(1-29). GAL(1-16). or D-trypt ophan(2)-GAL(1-29). These results indicate the presence of a distinct, yet- to-be cloned GAL(1-15)-selective receptor on CA3 neurons in the dorsal hipp ocampus.