Acute stress does not alter 5-HT1A receptor density

Authors
Steciuk, M Kram, M Kramer, GL Petty, F
Citation
M. Steciuk et al., Acute stress does not alter 5-HT1A receptor density, PROG NEUR-P, 24(1), 2000, pp. 155-161
Citations number
17
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN journal
02785846 → ACNP
Volume
24
Issue
1
Year of publication
2000
Pages
155 - 161
Database
ISI
SICI code
0278-5846(200001)24:1<155:ASDNA5>2.0.ZU;2-8
Abstract
1. Previous research suggests that 5-HT1A receptors are altered with exposu re to chronic stress. 2. No previous studies have examined the effect of acute stress on 5-HT1A. 3. Using receptor autoradiography it was observed that there were no differ ences in [3H]-8-OH-DPAT binding between control rats and rats that received 20 minutes of restraint stress 2 hours prior to sacrifice. 4. This study suggests that the changes in 5-HT1A receptor density associat ed with chronic stress develop over the course of repeated stress.