Dopamine transporter and D-2-receptor density in late-onset alcoholism

Rationale: Late onset type 1 alcoholism has been suggested to be associated with an underlying dopaminergic defect. Therefore, it is relevant to study both postsynaptic D-2-receptor and presynaptic dopamine transporter (DAT) densities among alcoholics. Objective We investigated DAT densities, along with striatal and extrastriatal dopamine D-2-receptor densities, in nine no n-violent late-onset male alcoholics, who had no major mental disorder nor antisocial personality disorder (ASPD), and nine healthy controls. Methods: [I-123]PE2I and [I-123]epidepride were used in SPECT imaging. Results: DAT occupancy ratios (striatum/cerebellum) were significantly lower among alco holics than in controls. Extrastriatal D-2-receptor occupancy ratios (tempo ral pole/cerebellum) were not significantly different between the groups. C onclusions: Striatal presynaptic DAT densities are decreased among type 1 a lcoholics, and this finding is not associated with recent alcohol abuse.