Accelerated hyperfractionated radiotherapy in 149 patients with glioblastoma multiforme

Authors
Lutterbach, J Weigel, P Guttenberger, R Hinkelbein, W
Citation
J. Lutterbach et al., Accelerated hyperfractionated radiotherapy in 149 patients with glioblastoma multiforme, RADIOTH ONC, 53(1), 1999, pp. 49-52
Citations number
24
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
RADIOTHERAPY AND ONCOLOGY
ISSN journal
01678140 → ACNP
Volume
53
Issue
1
Year of publication
1999
Pages
49 - 52
Database
ISI
SICI code
0167-8140(199910)53:1<49:AHRI1P>2.0.ZU;2-B
Abstract
Between August 1986 and December 1997, 149 patients with glioblastoma were treated postoperatively with 1.5 Gy fractions three times daily to a total dose of 54 Gy with 4-h intervals. Median actuarial survival was 8.8 months. Survival was 31% at 12 months and 3% at 24 months. No severe acute toxicit y occurred. Multivariate analysis revealed that only age less than or equal to 60 years and lactate dehydrogenase levels less than or equal to 240 U/l predicted significantly higher survival probabilities. (C) 1999 Elsevier S cience Ireland Ltd. All rights reserved.