STUDY OF ACETAMINOPHEN BY PARALLEL INCIDENT SPECTROELECTROCHEMISTRY

The oxidation process of acetaminophen at a platinum electrode was inv estigated by parallel incident spectroelectrochemistry (SEC). The form al potential (E-0') and the number of electrons transferred (n) were d etermined. The results revealed that the acetaminophen redox reaction was a diffusion-controlled one-electron quasireversible process, which was also confirmed by cyclic voltammetric experiments. The first step in the oxidation was a one-electron transfer reaction, first forming a free radical observed and proved by using Zn2+ as stabilizer, then t his free radical underwent a disproportionation reaction. Based on thi s, the content of acetaminophen in Suxiao Shangfeng Capsules was deter mined without pretreatment. The linear range of acetaminophen quantiza tion was 5 x 10(-5)-2 x 10(-4) mol/l with a correlation coefficient of 0.9985. The results showed that this method was simple and accurate.