Contribution to the development of oral dosage form for insulin delivery

This paper reviews the contribution of Francis Puisieux and his group to on e of the greatest challenges in pharmaceutical science, namely: the develop ment of an oral dosage form for insulin. We place twenty years of research research by Professor Puisieux and his colleagues in the context of a globa l effort to solve the problem of oral insulin. This review traces their wor k with liposomes, multiple emulsions and nanoparticles as insulin vehicles for oral delivery.