Optical resolution in two immiscible solvents in the presence of an intermediate solvent. Optical resolution of N-methyl-amphetamine by O,O '-dibenzoyl-R,R-tartaric acid in dichloroethane-water-methanol solvent system

A new optical resolution method was developed by the use of a two phase thr ee component solvent system and demonstrated on the example of the resoluti on of the N-methyl-amphetamine with O,O'-dibenzoyl-R,R-tartaric acid. By ad ding methanol as an intermediate solvent to the two phase water-dichloroeth ane solvent system the solubility and the optical purity of the precipitate d salt can be adjusted in wide ranges. By this way a highly efficient one s tep resolution process carl be accomplished.