ANTICARCINOGENIC AND ANTIMETASTATIC ACTIVITY OF ISCADOR

Methylcholanthrene-induced sarcoma formation in mice was found to be e ffectively inhibited by the intraperitoneal injection of mistletoe ext ract (Iscador M). Induction of sarcoma and sarcoma-induced death were inhibited completely at a concentration of 1 mg Iscador/dose. The conc entration needed for 50% inhibition was found to be 0.0166 mg Iscador/ dose. Mistletoe extract was also found to inhibit lung metastasis indu ced by B16F10 melanoma cells in mice. Simultaneous administration of t he Viscum album extract inhibited lung nodule formation by 92.0% and p roduced a 71.3% increase in life span.