Asymmetric reduction of 2-bromo-1-phenylethylidenemalononitrile with chiral NAD(P)H models

Authors
Li, J Liu, YC Deng, JG
Citation
J. Li et al., Asymmetric reduction of 2-bromo-1-phenylethylidenemalononitrile with chiral NAD(P)H models, TETRAHEDR-A, 10(22), 1999, pp. 4343-4347
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
22
Year of publication
1999
Pages
4343 - 4347
Database
ISI
SICI code
0957-4166(19991119)10:22<4343:ARO2WC>2.0.ZU;2-H
Abstract
Reduction of 2-bromo-1-phenylethylidenemalononitrile 1 with the chiral NAD( P)H model (S-s)-1-benzyl-3-(p-tolylsulfinyl)- 1,4-dihydropyridine 2 gives t he cyclopropane ring product (S)-2-phenylcyclopropane- 1,1-dicarbonitrile 3 with 54.5% enantiomeric purity. (C) 1999 Elsevier Science Ltd. Ail rights reserved.