Synthesis of (S)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide

Authors
Luke, GP Holt, DA
Citation
Gp. Luke et Da. Holt, Synthesis of (S)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide, TETRAHEDR-A, 10(22), 1999, pp. 4393-4403
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
22
Year of publication
1999
Pages
4393 - 4403
Database
ISI
SICI code
0957-4166(19991119)10:22<4393:SO(>2.0.ZU;2-E
Abstract
Three short syntheses of the title compound, a peptidomimetic for the Glu-G lu-Ile-NH2 portion of Ac-pTyr-Glu-Glu-Ile-NH2, a high affinity peptide for the Src SH2 domain, are described. The most efficient route produces the ti tle compound in a final enantiopurity of 94% ee. (C) 1999 Elsevier Science Ltd. All rights reserved.