Opportunities at the interface of chemistry and biology

The combination of the tools and principles of chemistry, together with the tools of modern molecular biology, allow us to create complex synthetic an d natural molecules, and processes with novel biological, chemical and phys ical properties. This article illustrates the tremendous opportunity that L ies at this interface of chemistry and biology by describing a number of ex amples, ranging from efforts to expand the genetic code of Living organisms to the use of combinatorial methods to generate biologically active synthe tic molecules.