Pattern formation in single cells (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999)

Citation
Jm. Shulman et D. St Johnston, Pattern formation in single cells (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999), TR CELL BIO, 9(12), 1999, pp. M60-M64
Citations number
45
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
09628924 → ACNP
Volume
9
Issue
12
Year of publication
1999
Pages
M60 - M64
Database
ISI
SICI code
0962-8924(199912)9:12<M60:PFISC(>2.0.ZU;2-R
Abstract
Single-cell patterning begins with an asymmetric cue that orients the axis of polarity. Despite great diversity in the types of cues, common mechanism s appear to mediate the polarizing response. Rho-family GTPases initially p rocess and reinforce polarity cues by remodelling cortical actin, and these Local asymmetries are subsequently propagated to the microtubules, membran e and secretory pathway to generate the final pattern. Homologues of the ye ast polarity genes fulfil similar functions in higher eukaryotes, revealing a fundamental conservation in how polarity arises. Unlike yeast, however, more complex eukaryotic cells can manifest multiple axes of polarity, sugge sting that additional mechanisms have evolved to generate more elaborate pa tterns.