Serological evidence of Chlamydia pneumoniae lipopolysaccharide antibodiesin atherosclerosis of various vascular regions

Background: The role of Chlamydia pneumoniae in the pathogenesis of atheros clerosis has so far mainly been investigated in patients suffering from cor onary heart disease; the other vascular regions have virtually been ignored . The aim of this study was to carry out a statistical survey of serologica l markers of a C. pneumoniae infection in patients with different patterns of atherosclerosis manifestation. Patients and methods: 340 patients were examined for the atherosclerotic al teration of peripheral arteries of the lower limbs, carotid arteries and co ronary arteries by ultrasound scan and/or angiography. Immunoglobulin(Ig) G and IgA-rELISA were used to measure chlamydial lipopolysaccharide antibodi es. Species determination was performed using the IgG micro-immunofluoresce nce test. Results: 24.0% of atherosclerotic cases (A) and 52.3% of controls (C) were negative for C. pneumoniae lipopolysaccharide antibodies (p = 0.00002). By contrast, 45.1% of atherosclerotic cases and 16.9% of controls were positiv e for both Ige and IgA (p 0.00002). The mean antibody titers of the atheros clerosis group were higher than in the control group (IgG positive x(A)IgG = 344, x(C)IgG = 272; IgG and IgA positive x(A)IgG = 576 x(C)IgG = 486 and x(A)IgA = 120, x(C)IgA = 91). Concerning atherosclerosis manifestation in v arious vascular regions, no significant differences were found between IgG and IgA antibody titers and prevalence. Conclusions: The results show that a persistent C. pneumoniae infection wit h evidence of lipopolysaccharide immunoglobulin G and A is equally associat ed with the atherosclerotic alteration of coronary arteries, carotid arteri es and peripheral arterial occlusive disease, irrespective of the severity of atherosclerosis and with no predisposition to any particular vascular re gion.