Correlation of hemodynamic and functional variables with the angiographic extent of peripheral arterial occlusive disease

The aim of the study was to determine whether hemodynamic and functional va riables are related to the angiographic extent of lower limb atherosclerosi s. In 150 patients with stable intermittent claudication, the Bollinger ang iogram score was compared with the resting Doppler pressure values, and the initial claudication distance (ICD) and absolute claudication distance (AC D) with treadmill exercise. The extent of lower limb atherosclerosis correl ated significantly with the age of the patients and the duration of the cla udication. The angiogram scores of the patients were negatively correlated with the ankle systolic blood pressure (SBP) and the ankle/brachial index ( ABI). In a multiple regression analysis, ABI was the most predictive variab le for the angiographic severity of disease. ICD, ACD and work on the tread mill failed to correlate with the angiogram summation score. If patients we re classified into groups for those with iliac or femoropopliteal disease, a weak correlation between ACD and femoropopliteal angiogram score was foun d. The comparison between Doppler measurements and treadmill exercise testi ng showed no significant correlation between SBP/ABI of the more diseased l imb and ICD. However, both SBP and ABI did correlate significantly with ACD (r = 0.16, p < 0.05 and r = 0.20, p < 0.01, respectively). In conclusion, SBP and ABI are reliable parameters for indirect assessment of the angiogra phic extent of lower limb atherosclerosis. In contrast, the walking capacit y of claudicant patients is independent of the angiographic severity of the disease.