Recurrent optic nerve head infarctions associated with combined factor V Leiden- and factor II : G20210A-mutation

Citation
C. Cursiefen et al., Recurrent optic nerve head infarctions associated with combined factor V Leiden- and factor II : G20210A-mutation, ACT OPHTH S, 77(6), 1999, pp. 625-627
Citations number
8
Categorie Soggetti
Optalmology
Journal title
ACTA OPHTHALMOLOGICA SCANDINAVICA
ISSN journal
13953907 → ACNP
Volume
77
Issue
6
Year of publication
1999
Pages
625 - 627
Database
ISI
SICI code
1395-3907(199912)77:6<625:RONHIA>2.0.ZU;2-X
Abstract
Purpose: To demonstrate the association of bilateral recurrent optic nerve head infarctions with thrombophilia due to combined factor V:R506Q- and fac tor II:G20210A-mutation. Methods: Case report. We examined a 55-year-old man with a two-year history of three segmental optic nerve head infarctions. Visual acuity was 20/80 o n the left and 20/25 on the right eye. Results: Ophthalmologic, cardiologic, radiologic, neurologic and hematologi c-immunologic examinations were unremarkable except for increased APC-resis tance (APC ratio: 1.4; normal value >2) due to heterozygous factor V:R506Q- mutation and high factor II-leveIs due to factor If:G20210A-mutation, Thera py with coumarin was instituted at INR 2.0-3.0 and no relapse has occurred over the past 1-year period. Conclusion: Combined occurrence of thrombogenic factor II:G20210A-mutation and factor V:R506Q-mutation may be causally linked to recurrent optic nerve head infarctions.