Y. Arai et al., A patient with genetic deletion of glutathione-S-transferase T1 and M1 whodeveloped non-small-cell lung cancer and myelodysplastic syndromes, AM J MED SC, 318(6), 1999, pp. 424-427
Citations number
19
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibil
ity to smoking-related neoplasms, such as lung and bladder cancer. Recently
, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be
associated with myelodysplastic syndromes (MDS). A 59-year-old man with a
long-term smoking habit was treated successfully for non-small-cell lung ca
ncer. Four years after the surgical removal of his lung cancer, he develope
d MDS and died. Using a polymerase chain reaction-based genotyping method,
he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screenin
g for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing
individual genetic susceptibility to smoking-related lung cancer and MDS.