A patient with genetic deletion of glutathione-S-transferase T1 and M1 whodeveloped non-small-cell lung cancer and myelodysplastic syndromes

Citation
Y. Arai et al., A patient with genetic deletion of glutathione-S-transferase T1 and M1 whodeveloped non-small-cell lung cancer and myelodysplastic syndromes, AM J MED SC, 318(6), 1999, pp. 424-427
Citations number
19
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
ISSN journal
00029629 → ACNP
Volume
318
Issue
6
Year of publication
1999
Pages
424 - 427
Database
ISI
SICI code
0002-9629(199912)318:6<424:APWGDO>2.0.ZU;2-5
Abstract
Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibil ity to smoking-related neoplasms, such as lung and bladder cancer. Recently , a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung ca ncer. Four years after the surgical removal of his lung cancer, he develope d MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screenin g for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.