Use of automated HPLC-MS analysis for monitoring and improving the purity of combinatorial libraries

Authors
Greig, M
Citation
M. Greig, Use of automated HPLC-MS analysis for monitoring and improving the purity of combinatorial libraries, AM LABORAT, 31(24), 1999, pp. 28
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
AMERICAN LABORATORY
ISSN journal
00447749 → ACNP
Volume
31
Issue
24
Year of publication
1999
Database
ISI
SICI code
0044-7749(199912)31:24<28:UOAHAF>2.0.ZU;2-4
Abstract
Analyzing the components of a combinatorial library that often number in ex cess of 20,000 is a major bottleneck in the drug discovery process. The aut omated HPLC-MS system described in this article measures the purity of each sample in the library and automatically exports the results into a databas e in a process that employs only one part-time laboratorian.