New N-1-hetarylmethylene-substituted amidrazones with potential antimycobacterial activity

N-1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substitut ed picolinic acid amidrazones and pyrazine-2-carboxamidrazones were investi gated. The compounds were accessible by reaction of the unsubstituted amidr azones with aldehydes. Pyrazine-2-carbox-N-1-(2-benzoxazolymethylene)amidra zones were obtained by a new multistep reaction. The investigated amidrazon es were tested for their antibacterial activity against four strains of myc obacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.