In a bioassay-guided search for anti-allergic compounds from higher plants
of Korea, polymethoxyflavones, 3 ',4',5,6',7,8-hexamethoxyflavone (I), 5-hy
droxy-3',4',6,7,8-pentamethoxyflavone (II) and 3',4',5,7,8,-pentamethoxyfla
vone (III) have been isolated from the immature peels of Citrus unshiu. Str
uctures of these compounds were elucidated on the basis of spectroscopic te
chniques. Compounds I and II inhibited dose-dependently histamine release f
rom the rat peritoneal mast cells activated by compound 48/80 or anti-DNP I
gE.