The acute pathology of fatty acid anilides and linoleic diester of 3-phenylamino-1,2-propanediol in mice: possible implication as aetiologic agents for the toxic oil syndrome

Two groups of compounds, the fatty acid anilides and the mono- and diester of 3-phenylamino-1,2-propanediol (PAP) are suspected as aetiologic agents f or the toxic oil syndrome (TOS). Intraperitoneal administration of oleoyl a nd linoleoyl anilides in mice caused severe weight loss followed by death i n 50% of the animals and histopathological changes mainly to the lungs. Lin oleic diester of PAP led to weight loss, haemorrhage, congestion and emphys ema in the lungs and an increase in blood eosinophilia. Although not produc ing the full spectrum of symptoms the effects of the substances resemble th e acute human disease. Possibly, the two groups of substances led together to the full spectrum of disease manifestations seen in TOS.