GLUCOSE-STIMULATED SODIUM-TRANSPORT BY THE HUMAN INTESTINE DURING EXPERIMENTAL CHOLERA

Citation
Lr. Schiller et al., GLUCOSE-STIMULATED SODIUM-TRANSPORT BY THE HUMAN INTESTINE DURING EXPERIMENTAL CHOLERA, Gastroenterology, 112(5), 1997, pp. 1529-1535
Citations number
33
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
00165085
Volume
112
Issue
5
Year of publication
1997
Pages
1529 - 1535
Database
ISI
SICI code
0016-5085(1997)112:5<1529:GSBTHI>2.0.ZU;2-U
Abstract
Background & Aims: Net sodium absorption from oval rehydration solutio n is increased by both glucose-sodium cotransport and solvent drag. Th e aim of this study was to measure the relative importance of glucose- sodium cotransport and solvent drag in the stimulation of net sodium a bsorption by oral rehydration solution. Methods: Total intestinal perf usion was used in normal subjects with and without intrajejunal choler a toxin using three test solutions containing 100 mmol/L sodium and ei ther 100 mmol/L mannitol (control), 100 mmol/L glucose, or no addition al solute (hypotonic solution). The increase in sodium absorption grea ter than control with hypotonic solution represented sodium absorption stimulated by solvent drag; the further increase in sodium absorption induced by glucose, greater than that noted with the hypotonic soluti on, represented sodium absorption stimulated by cotransport. Results: Without cholera toxin, solvent drag and cotransport promoted sodium ab sorption at rates of 62 and 33 mmol/h, respectively. With cholera toxi n, solvent drag and cotransport promoted sodium absorption at rates of 44 and 71 mmol/h, respectively. Conclusions: Net sodium absorption ca used by cotransport increased move than twofold after exposure of the intestine to cholera toxin (P < 0.003). This could be mediated by incr eased cotransport, a change in the stoichiometry of cotransport, or an increase in chloride permeability.