Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients

Authors
Gracheva, EV Golovanova, NK Ezhov, MV Malyshev, PP Kukharchuk, VV Prokazova, NV
Citation
Ev. Gracheva et al., Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients, BIOCHEM-MOS, 64(11), 1999, pp. 1315-1319
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMISTRY-MOSCOW
ISSN journal
00062979 → ACNP
Volume
64
Issue
11
Year of publication
1999
Pages
1315 - 1319
Database
ISI
SICI code
0006-2979(199911)64:11<1315:PSAIHS>2.0.ZU;2-P
Abstract
Plasma sialyltransferase activity measured by incorporation of cytidine 5'- phospho[C-14]acetylneuraminic acid (CMP-NeuAc) into asialofetuin was twofol d higher in patients with documented atherosclerosis than in healthy donors . Kinetic studies showed that the enzyme affinity for CMP-NeuAc is the same in donors and patients. Low activity of plasma sialyltransferase in donors may be due to low blood content of this enzyme.