How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?

Authors
Baird, B Sheets, ED Holowka, D
Citation
B. Baird et al., How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?, BIOPHYS CH, 82(2-3), 1999, pp. 109-119
Citations number
50
Categorie Soggetti
Biochemistry & Biophysics","Physical Chemistry/Chemical Physics
Journal title
BIOPHYSICAL CHEMISTRY
ISSN journal
03014622 → ACNP
Volume
82
Issue
2-3
Year of publication
1999
Pages
109 - 119
Database
ISI
SICI code
0301-4622(199912)82:2-3<109:HDTPMP>2.0.ZU;2-V
Abstract
Accumulating evidence strongly supports the view that the plasma membrane p articipates in transmembrane signaling by IgE-receptors (IgE-Fc epsilon RI) through the formation of lipid-based domains, also known as rafts. Ongoing biochemical and biophysical experiments investigate the composition, struc ture, and dynamics of the corresponding membrane components and how these a re related to functional coupling between Fc epsilon RI and Lyn tyrosine ki nase to initiate signaling in mast cells. (C) 1999 Elsevier Science B.V. Al l rights reserved.