Griseofulvin is an antifungal antibiotic and is used for the treatment of m
ycotic diseases of human, veterinary and plant systems. It is synthesised b
y many species of Penicillium. The exploitation of fermentation process pla
ys a vital role in the industrial applications. This leads to techno-econom
ic feasibility of the processes. The present review mainly discusses on the
production of griseofulvin in soil, in plants and by various micro-organis
ms. This communication also summarises the various factors which influence
the griseofulvin production and strain improvement by mutation for enhanced
production.