Fifty-year follow-up of cancer incidence in a historical cohort of Minnesota breast cancer families

A family history of breast cancer is well established as a risk factor for the disease. Because family history is a dynamic rather than a static chara cteristic, longitudinal studies of entire families can be very instructive in quantifying the significance of risk classification. The Minnesota Breas t Cancer Family Study is a historical cohort study of relatives of a consec utive series of 426 breast cancer cases (probands) identified between 1944 and 1952. The incidence of cancer and the measurement of risk factors in si sters, daughters, granddaughters, nieces, and marry-ins was determined thro ugh telephone interviews and mailed questionnaires. Ninety-eight percent of eligible families were recruited, and 93% of members participated. A total of 9073 at-risk women were studied: 56% were biological relatives of the c ase probands, whereas the others were related through marriage. Through 199 6, 564 breast cancers were identified in nonprobands. Compared to the rate of breast cancer among marry-ins (188 cases), sisters and daughters of the probands were at a 1.9-fold greater age-adjusted risk (128 cases; 95% confi dence interval, 1.4-2.4); granddaughters and nieces were at a 1.5-fold grea ter risk (248 cases, 95% confidence interval, 1.2-1.8). The breast cancer r isk since 1952 was not distributed equally across families: although all bi ological relatives had a family history of breast cancer, 166 families (39% ) experienced no additional cases. Most of the cases occurred among a subse t of families: 21 families had 5 breast or ovarian cancers, 8 had 6, 2 had 7, and 4 had greater than or equal to 8. There was no evidence of significa ntly increased risk for cancer at other sites, including the ovaries, cervi x, uterus, colon, pancreas, stomach, or lymphatic tissue, although there wa s some evidence that stomach cancer in previous generations may help define the susceptible subset. These families contain four to five generations of validated occurrences of cancer, thus minimizing the uncertainty of geneti c risk inherent in a disease with a late and variable age at onset. The pat terns of breast cancer in these multigeneration families is consistent with the influence of autosomal dominant susceptibility in a subset, low penetr ance genes in another, and purely environmental influences in the remainder .