Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells

Androgens via their receptor (AR) may play a role in prostate cancer etiolo gy. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol r epresses different classes of androgen up-regulated genes at the protein or mRNA level including prostate-specific antigen, human glandular kallikrein -2, AR-specific coactivator ARA70, and the cyclin-dependent kinase inhibito r p21. This inhibition is likely attributable to a reduction in AR contents at the transcription level, inhibiting androgen-stimulated cell growth and gene expression. This study suggests that resveratrol may be a useful chem opreventive/chemotherapeutic agent for prostate cancer.