Mouse electrocardiography: An interval of thirty years

The interest in mouse electrophysiology is expanding fast, despite the mark ed differences between mouse and man. Different methods have become availab le to analyse the electrical activity in the mouse heart in vivo. The mouse genome can be altered with relative ease, which allows the molecular disse ction of the various components that contribute to de- and repolarisation o f the cardiomyocyte and the initiation and propagation of cardiac arrhythmi as. Mouse ischaemia reperfusion models have been used recently to study pre ventive measures against ischaemic myocyte damage. In the present review, t he electrophysiological measurements performed in mice to date are discusse d and complemented with results from a mouse ischaemia reperfusion model. ( C) 2000 Elsevier Science B.V. AU rights reserved.