New regioselective total syntheses of antibiotic renierol, renierol acetate, and renierol propionate from the 5-oxygenated isoquinoline

Authors
Kuwabara, N Hayashi, H Hiramatsu, N Choshi, T Sugino, E Hibino, S
Citation
N. Kuwabara et al., New regioselective total syntheses of antibiotic renierol, renierol acetate, and renierol propionate from the 5-oxygenated isoquinoline, CHEM PHARM, 47(12), 1999, pp. 1805-1807
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
12
Year of publication
1999
Pages
1805 - 1807
Database
ISI
SICI code
0009-2363(199912)47:12<1805:NRTSOA>2.0.ZU;2-T
Abstract
New total syntheses of renierol (3), renierol acetate (4), and renierol pro pionate (5) were completed by the synthesis of 5-oxygenated isoquinoline (6 ) based on the thermal electrocyclic reaction of the 1-azahexatriene system followed by regioselective oxidations of 5-hydroxyisoquinolines (6).