Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND)

Authors
Johannes, C Chudoba, I Obe, G
Citation
C. Johannes et al., Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND), CHROMOS RES, 7(8), 1999, pp. 625-633
Citations number
42
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CHROMOSOME RESEARCH
ISSN journal
09673849 → ACNP
Volume
7
Issue
8
Year of publication
1999
Pages
625 - 633
Database
ISI
SICI code
0967-3849(199912)7:8<625:AOXAIH>2.0.ZU;2-9
Abstract
Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were ana lysed in human chromosome 5 using high-resolution multicolour banding fluor escence in-situ hybridization (mBAND). This method is suited to detect simp le and complex aberrations including peri- and paracentric inversions and e xchanges between both chromosomes 5. Additionally, breakpoints can be assig ned to specific regions in chromosome 5. Quantitative relationships of indu ced aberration types are discussed.