Ar. Gaynor et N. Dhupa, Acute ethylene glycol intoxication. Part II. Diagnosis, treatment, prognosis, and preventions, COMP CONT E, 21(12), 1999, pp. 1124
Citations number
65
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
COMPENDIUM ON CONTINUING EDUCATION FOR THE PRACTICING VETERINARIAN
Acute ethylene glycol (EG) intoxication is a rapidly progressive, life-thre
atening emergency with a complex pathophysiology-the key features of which
include hyperosmolality, high anion gap metabolic acidosis, and acute oligu
ric renal failure. Rapid diagnosis is critical and requires a strong index
of suspicion and often repeat analyses. Antidotal therapy is based on preve
nting biotransformation of EG to its toxic metabolites; however, intensive
physiologic monitoring and aggressive use of intravenous fluids and sodium
bicarbonate are also essential components of treatment. Despite advances in
our understanding of the pathophysiology and therapy of EG intoxication, m
ost animals are presented already in oliguric renal failure and may require
hemodialysis or peritoneal dialysis to survive the effects of this intoxic
ation.