Effects of Conus peptides on the behavior of mice

When different cone snail peptides are injected into the CNS of vertebrates , they elicit diverse behaviors primarily because of their selectivity for specific receptor or ion channel subtypes. The subcellular context of the h ighly localized targets (i,e, the presence of other cellular elements that are functionally linked to the targets of conopeptides) is another determin ant of the elicited behavior, Recent studies have advanced our understandin g of the mechanisms by which four conopeptides produce different behaviors in mice.