Inclusion body myositis

Sporadic inclusion body myositis is a severely disabling muscle disease tha t mainly affects elderly individuals. The typical distribution of muscle we akness, poor response to immunosuppressive treatment, pathological accumula tion of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of recent research that h as led to better understanding of the pathogenic events that leads to muscl e degeneration and weakness. Curr Opin Neurol 12:527-533. (C) 1999 Lippinco tt Williams & Wilkins.