In the general population depression may pre-date alcohol disorders in wome
n but seldom in men. Support for the self-medication hypothesis is inconsis
tent; support grows for a common genetic basis for these disorders in some
individuals. There may also be a genetic basis for the association between
alcohol dependence and attention - deficit hyperactivity disorder and serot
onin is implicated. Medications and cognitive therapy can be effective. Cur
l Opin Psychiatry 12:297-301. (C) 1999 Lippincott Williams & Wilkins.