Selective redox reaction of a hydrophobic mediator on a self-assembled monolayer electrode and its application to a high performance enzyme sensor

Electrochemical oxidation of ascorbic acid was significantly suppressed on a 11-mercaptoundecanoic acid (MUA)-assembled gold electrode, whereas redox reaction of ferrocenylmethanol was not retarded on the same electrode. The selective oxidation reaction of the hydrophobic mediator was utilized for a n amperometric glucose sensing by using a glucose oxidase-immobilized MUA e lectrode. It was shown that the surface-ordered electrode was useful for se lective amperometric biosensing in which interference from ascorbic acid wa s excluded.