Mp. Longnecker et Je. Michalek, Serum dioxin level in relation to diabetes mellitus among Air Force Veterans with background levels of exposure, EPIDEMIOLOG, 11(1), 2000, pp. 44-48
Citations number
35
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Data from several epidemiologic studies suggest that exposure to unusually
high amounts of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) increases the
risk of diabetes mellitus, and experimental data suggest that the mechanism
for this is decreased cellular glucose uptake. To investigate the dose-res
ponse relation more closely, we examined the association of serum dioxin le
vel with prevalence of diabetes mellitus and with levels of serum insulin a
nd glucose among 1,197 veterans in the Air Force Health Study who never had
contact with dioxin-contaminated herbicides and whose serum dioxin level w
as within the range of background exposure typically seen in the United Sta
tes (less than or equal to 10 ng/kg lipid). Compared with those whose serum
dioxin level was in the first quartile (<2.8 ng/kg lipid), the multivariat
e adjusted odds of diabetes among those in the highest quartile (greater th
an or equal to 5.2 ng/kg lipid) was 1.71 (95% confidence interval = 1.00-2.
91). The association was slightly attenuated after adjustment for serum tri
glycerides. Whether adjustment for serum triglycerides was appropriate, how
ever, cannot be determined with available data. The association of backgrou
nd-level dioxin exposure with the prevalence of diabetes in these data may
well be due to reasons other than causality, although a causal contribution
cannot be wholly dismissed.