In this paper the question is posed whether it is not only better for
the animal to be happy, but whether its state of mind may also have th
e potential to influence the scientific results derived from it. To en
sure good science, the animal should have a normal physiology and beha
viour, apart from specific adverse effects under investigation. There
is a growing body of evidence from a wide variety of sources to show t
hat animals whose well-being is compromised are often physiologically
and immunologically abnormal and that experiments using them may reach
unreliable conclusions. On scientific, as well as ethical grounds, th
erefore, the psychological well-being of laboratory animals should be
an important concern for veterinarians, animal technicians and scienti
sts.