WIEDEMANN-RAUTENSTRAUCH NEONATAL PROGEROID SYNDROME - REPORT OF 3 NEWPATIENTS

Wiedemann-Rautenstrauch (WR) syndrome is known as a neonatal progeroid syndrome, with only few published case reports. We describe three add itional patients, two of them sibs, showing the clinical features of W R syndrome. Skeletal abnormalities are reported and assays of hormones and lipids are presented in one patient. Disturbance in bone maturati on and lipid and hormone metabolism appear to be involved in this neon atal progeroid syndrome.