Toxoplasma gondii is an important cause of disease, in pregnant women, newb
orns and immunocompromised hosts. Infection with I:gondii naturally occurs
through ingestion of raw or undercooked meat containing cysts or through co
ntact with cat feces containing oocysts. The intestine thus appears to be t
he site of invasion of the parasite. Since acute infection in immunocompete
nt hosts usually goes unnoticed, no information is available regarding the
involvement of the intestine during acute infection in humans. However, in
murine models of the disease the acute phase of infection has not been inve
stigated in detail as well. In this report, an overview of the current know
ledge regarding the initial phase of infection with T. gondii is given. Res
ults of studies focussing on invasion and dissemination of the parasite and
the immune responses elicited in the intestine are reviewed. The impact on
the induction of local immune responses of the genetic background and sex
of mice as well as the role of different doses and strains of the parasite
are discussed. Finally, reports on the development of intestinal pathology
in different animal species and the involvement of the intestine in human d
isease are reviewed.