FATTY-ACID COMPOSITION OF ADIPOSE-TISSUE, AN INDICATION OF DIETARY FATTY-ACIDS, AND BREAST-CANCER PROGNOSIS

Purpose: Fatty acid composition of adipose tissue is an indicator of t he long-term ingestion pattern of several specific fatty acids. There is good correlation of antecedent diet with the essential fatty acids, and there is reflection of the diet with the fatty acids that can be synthesized. The relationship between the fatty acid levels and lymph node status and clinical outcome was examined. Methods: At the time of diagnostic surgery, 161 women with clinical stage T1N0 breast cancer had subcutaneous adipose tissue (breast and abdominal) aspirated. The concentrations of 35 fatty acids, seven summed classes, and six fatty acid groups were measured by capillary gas chromatography. Lymph node status was determined with axillary dissection, and patients were foll owed-up (mean, 7.3 years) for clinical outcome. Results: There was no significant association of any adipose tissue fatty acids with overall survival, although few (16 of 161 women) died of breast cancer, Howev er, the odds of having positive lymph nodes (57 of 161 women) were sig nificantly higher for women with a greater adipose tissue proportion o f oleic acid (odds ratio [OR], 7.56; 95% confidence interval [CI], 1.7 8 to 32.1) or total saturated acids (OR, 8.43; 95% CI, 1.48 to 40.0) a nd significantly lower with a higher proportion of trans fatty acids ( OR, 0.24; 95% CI, 0.07 to 0.77), as assessed by multivariate logistic regression. Conclusion: These data support previous research with diet ary questionnaire methodology, suggesting that specific dietary fatty acids may be associated with breast cancer promotion, Further research with long-term clinical follow-up is necessary to investigate these o bservations in large, diverse populations before dietary recommendatio ns can be envisioned. (C) 1991 by American Society of Clinical Oncolog y.