Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)

Authors
Kawamoto, H Ozaki, S Itoh, Y Miyaji, M Arai, S Nakashima, H Kato, T Ohta, H Iwasawa, Y
Citation
H. Kawamoto et al., Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397), J MED CHEM, 42(25), 1999, pp. 5061-5063
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
00222623 → ACNP
Volume
42
Issue
25
Year of publication
1999
Pages
5061 - 5063
Database
ISI
SICI code
0022-2623(199912)42:25<5061:DOTFPA>2.0.ZU;2-H