Congenital heart defects and maternal derangement of homocysteine metabolism

Authors
Kapusta, L Haagmans, MLM Steegers, EAP Cuypers, MHM Blom, HJ Eskes, TKAB
Citation
L. Kapusta et al., Congenital heart defects and maternal derangement of homocysteine metabolism, J PEDIAT, 135(6), 1999, pp. 773-774
Citations number
6
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
JOURNAL OF PEDIATRICS
ISSN journal
00223476 → ACNP
Volume
135
Issue
6
Year of publication
1999
Pages
773 - 774
Database
ISI
SICI code
0022-3476(199912)135:6<773:CHDAMD>2.0.ZU;2-6
Abstract
Methionine loading tests and folate, vitamin B-6, and vitamin B-12 analyses were performed in 27 mothers of children with congenital heart defects. Me dian fasting plasma homocysteine concentrations were significantly higher i n the study group as compared with 56 control subjects (P =.0001). Maternal hyperhomocysteinemia may be a risk factor for congenital heart defects.