Electrochemical study on the determination of tinidazole in tablets

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongl y acidic solution (pH < 4.5), one reduction peak was obtained and it was su itable for analytical purposes. A method for the determination of tinidazol e by DP polarography in Britton-Robinson buffer of pH 3.0, which allows qua ntification over the range 0.03-7.30 mu g/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mea n recovery and relative standard deviation of 98.7 and 3%, respectively. Ex cipients did not interfere in the determination. (C) 1999 Elsevier Science B.V. All rights reserved.