Molecular mechanism of HF acid ionization in water: An electronic structure - Monte Carlo study

The results of a theoretical study of the acid ionization to form first a c ontact ion pair and then a solvent-separated ion pair are presented for HF in water. The ionization reaction to produce the contact ion pair is found to involve adiabatic quantum proton transfer (PT) and has an activation bar rier in a collective solvent reaction coordinate of 2.9 kcal/mol, with a po sitive reaction free energy estimated as 2.2 kcal/mol. This result identifi es the weakness of HF acid in aqueous solution as arising from this intrins ic acid ionization step, rather than from the thermodynamic difficulty of s eparating the ions so produced. The calculated charge distributions for the first step are in support of the unconventional Mulliken picture for PT. T he second step to produce a solvent-separated ion pair is found to be seque ntial in connection with the first step, rather than concerted, and is also a quantum adiabatic PT. This reaction step proceeds via a solvent reaction coordinate and is slightly activated. The two step sequence in reverse ord er is discussed in connection with the Eigen picture of acid-base recombina tion in aqueous solution.