Acute promyelocytic leukemia with del(6)(p23)

Authors
Nakase, K Wakita, Y Minamikawa, K Yamaguchi, T Shiku, H
Citation
K. Nakase et al., Acute promyelocytic leukemia with del(6)(p23), LEUK RES, 24(1), 2000, pp. 79-81
Citations number
13
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
24
Issue
1
Year of publication
2000
Pages
79 - 81
Database
ISI
SICI code
0145-2126(200001)24:1<79:APLWD>2.0.ZU;2-5
Abstract
We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patie nt had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abn ormalities. Molecular analyses revealed the presence of PML-RAR alpha fusio n genes. Deletion of the 6p23 region is extremely rare in APL. (C) 1999 Els evier Science Ltd. All rights reserved.