Sweet's syndrome accompanying leukaemia: seven cases and review of the literature

Seven patients with Sweet's Syndrome (SS) accompanying leukaemia are presen ted. Six had acute myeloid leukaemia and one chronic myeloid leukaemia. SS developed during G-CSF therapy in two patients and following long periods o f chemotherapy-associated neutropenia in two. This finding may suggest a po ssible role of G-CSF in the pathogenesis of SS. SS was diagnosed during the first presentation of three patients with leukaemia. Skin lesions on the l ower extremiteies in two patients, widespread distribution in one, a local infiltration at the inguinal region and pleural effusion in one were intere sting findings in our patients which are not usual for classical SS. (C) 19 99 Elsevier Science Ltd. All rights reserved.